Platelet concentrates, like platelet-rich plasma (PRP) and platelet lysate (PL), are widely used in regenerative medicine, especially in bone regeneration. However, the lack of standard procedures and controls leads to high variability in the obtained results, limiting their regular clinical use. Here, we propose the use of platelet-derived extracellular vesicles (EVs) as an off-the-shelf alternative for PRP and PL for bone regeneration. In this article, we evaluate the effect of PL-derived EVs on the biocompatibility and differentiation of mesenchymal stromal cells (MSCs).

中文翻译：

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血小板衍生的细胞外囊泡促进间充质基质细胞的骨诱导。

血小板浓缩物，如富血小板血浆 (PRP) 和血小板裂解物 (PL)，广泛用于再生医学，尤其是骨再生。然而，缺乏标准程序和控制导致所获得结果的高度可变性，限制了它们的常规临床使用。在这里，我们建议使用血小板衍生的细胞外囊泡 (EV) 作为 PRP 和 PL 用于骨再生的现成替代品。在本文中，我们评估了 PL 衍生的 EVs 对间充质基质细胞 (MSCs) 的生物相容性和分化的影响。