The relationship between serum lipid profiles and related clinicopathologic features of IgA nephropathy (IgAN) and c-Maf-inducing protein (CMIP) gene polymorphisms is unclear. The present study was designed to examine the effect of CMIP single-nucleotide polymorphisms (SNPs) on dyslipidaemia and clinicopathologic features of IgAN. Clinical and pathological data from patients with IgAN diagnosed at the First Affiliated Hospital of Guangxi Medical University were collected. DNA was extracted from blood samples. CMIP rs2925979 and CMIP rs16955379 genotypes were determined by PCR and direct sequencing. Among 543 patients, 281 had dyslipidaemia (51.7%). Compared with the non-dyslipidaemia group, the dyslipidaemia group exhibited higher blood pressure, blood urea nitrogen, uric acid, and body mass index; higher prevalence of oedema, haematuria, tubular atrophy, and interstitial fibrosis; and lower albumin and estimated glomerular filtration rate. In the dyslipidaemia group, the frequency of C allele carriers was higher than that of non-C allele carriers for rs16955379. Multivariate linear regression analysis showed that total cholesterol, low-density lipoprotein and high-density lipoprotein were associated with rs16955379C allele carriers. Apolipoprotein B was associated with A allele carriers of rs2925979. Linkage disequilibrium was observed between rs16955379 and rs2925979, and rs2925979G-rs16955379T was the most common haplotype. The frequencies of the four CMIP SNP haplotypes differed between dyslipidaemia and non-dyslipidaemia groups in IgAN (P<0.05, for all above). Dyslipidaemia is a common complication in IgAN patients, and those with dyslipidaemia present poor clinicopathologic features. CMIP SNPs and their haplotypes are closely correlated with the occurrence of dyslipidaemia and clinicopathologic damage in IgAN patients.

中文翻译：

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CMIP SNP及其单倍型与血脂异常和IgA肾病的临床病理特征有关。

血清脂质谱与IgA肾病（IgAN）和c-Maf诱导蛋白（CMIP）基因多态性的相关临床病理特征之间的关系尚不清楚。本研究旨在检查CMIP单核苷酸多态性（SNP）对血脂异常和IgAN的临床病理特征的影响。收集广西医科大学附属第一医院确诊的IgAN患者的临床和病理资料。从血液样本中提取DNA。通过PCR和直接测序确定CMIP rs2925979和CMIP rs16955379的基因型。在543名患者中，有281名患有血脂异常（51.7％）。与非血脂异常组相比，血脂异常组的血压，血尿素氮，尿酸和体重指数更高；水肿，血尿，肾小管萎缩和间质纤维化；较低的白蛋白和估计的肾小球滤过率。在血脂异常组中，rs16955379的C等位基因携带者频率高于非C等位基因携带者。多元线性回归分析显示总胆固醇，低密度脂蛋白和高密度脂蛋白与rs16955379C等位基因携带者相关。载脂蛋白B与rs2925979的A等位基因携带者相关。rs16955379和rs2925979之间观察到连锁不平衡，而rs2925979G-rs16955379T是最常见的单倍型。在IgAN的血脂异常组和非血脂异常组中，四种CMIP SNP单倍型的频率有所不同（以上均P <0.05）。血脂异常是IgAN患者的常见并发症，血脂异常者的临床病理特征较差。CMIP SNP及其单倍型与IgAN患者血脂异常的发生和临床病理损害密切相关。