Almost 40 years ago, the world was noticing the emergence of one of the major public health threats it has ever known: HIV. Facing the cost-effectiveness and the health-related issues encountered with antiretroviral treatments, scientists have imagined and conceived gene therapies to tackle HIV infection. The success of such an approach was proved with the "Berlin" patient then recently reiterated in the "London" patient. In fact, the recent progress made in HIV gene therapy could provide a rapid emergence of powerful strategies to treat and totally cure the infection. Based on their principles, these approaches can be separated in three strategies that are (1) engineering HIV target cells to render them resistant to HIV replication, (2) generating genemodified cells able to secrete antiviral proteins that interfere with HIV entry, and (3) modifying cytotoxic T cells to selectively target and eliminate infected cells. Herein, we proposed to review these approaches, their safety and their benefits as reported in recent publications.

中文翻译：

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HIV 基因治疗策略和安全性：我们从最近的出版物中了解到什么？

大约 40 年前，世界注意到它所知道的主要公共卫生威胁之一的出现：艾滋病毒。面对抗逆转录病毒治疗的成本效益和健康相关问题，科学家们已经想象并构思了基因疗法来解决艾滋病毒感染。这种方法的成功在“柏林”患者身上得到了证明，然后最近在“伦敦”患者身上得到了重申。事实上，最近在 HIV 基因治疗方面取得的进展可以提供治疗和完全治愈感染的强大策略的快速出现。根据它们的原理，这些方法可以分为三种策略：(1) 改造 HIV 靶细胞以使其具有抗 HIV 复制的能力，(2) 产生能够分泌干扰 HIV 进入的抗病毒蛋白的基因修饰细胞，以及 (3) 修饰细胞毒性 T 细胞以选择性地靶向和消除受感染的细胞。在此，我们提议审查最近出版物中报道的这些方法、它们的安全性和它们的益处。