TIP60/P400/H4K12ac Plays a Role as a Heterochromatin Back-up Skeleton in Breast Cancer.,Cancer Genomics & Proteomics

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TIP60/P400/H4K12ac Plays a Role as a Heterochromatin Back-up Skeleton in Breast Cancer.
Cancer Genomics & Proteomics ( IF 2.5 ) Pub Date : 2020-10-26 , DOI: 10.21873/cgp.20223
Mouhamed Idrissou _{1,

2} , Tiphanie Boisnier _{1,

2} , Anna Sanchez _{1,

2} , Fatma Zohra Houfaf Khoufaf _{1,

2} , Frederique Penault-Llorca _{2,

3} , Yves-Jean Bignon _{1,

2} , Dominique Bernard-Gallon _{2,

4}

Affiliation

In breast cancer, initiation of carcinogenesis leads to epigenetic dysregulation, which can lead for example to the loss of the heterochromatin skeleton SUV39H1/H3K9me3/HP1 or the supposed secondary skeleton TIP60/P400/H4K12ac/BRD (2/4), which allows the maintenance of chromatin integrity and plasticity. This study investigated the relationship between TIP60, P400 and H4K12ac and their implications in breast tumors.

中文翻译：

TIP60 / P400 / H4K12ac在乳腺癌中起着异染色质备用骨架的作用。

在乳腺癌中，致癌作用的开始会导致表观遗传失调，这可能导致例如异染色质骨架SUV39H1 / H3K9me3 / HP1或所谓的次要骨架TIP60 / P400 / H4K12ac / BRD（2/4）丢失。保持染色质的完整性和可塑性。这项研究调查了TIP60，P400和H4K12ac之间的关系及其在乳腺肿瘤中的意义。

更新日期：2020-10-31

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