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The KDR (VEGFR-2) Genetic Polymorphism Q472H and c-KIT Polymorphism M541L Are Associated With More Aggressive Behaviour in Astrocytic Gliomas.
Cancer Genomics & Proteomics ( IF 2.6 ) Pub Date : 2020-10-26 , DOI: 10.21873/cgp.20226
Niyaz Zaman 1 , Serena Santhana Dass 1 , Persephone DU Parcq 2 , Suzanne Macmahon 3 , Lewis Gallagher 3 , Lisa Thompson 3 , Jamshid S Khorashad 4 , Clara LimbÄck-Stanic 1, 2
Affiliation  

Better diagnostic and prognostic markers are required for a more accurate diagnosis and an earlier detection of glioma progression and for suggesting better treatment strategies. This retrospective study aimed to identify actionable gene variants to define potential markers of clinical significance.

中文翻译:

在星形胶质瘤中,KDR(VEGFR-2)遗传多态性Q472H和c-KIT多态性M541L与更具攻击性的行为相关。

需要更好的诊断和预后标志物,以进行更准确的诊断和更早地检测神经胶质瘤的进展,并提出更好的治疗策略。这项回顾性研究旨在确定可操作的基因变异体,以定义具有临床意义的潜在标志物。
更新日期:2020-10-31
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