Malignant pilomatricoma (MP) is a rare cancer of the hair matrix with only a few cases reported in literature. Given the rarity of this cancer and the lack of relevant genetic data, very little is known about the nature of the molecular pathophysiology except the involvement of the Catenin Beta 1 (CTNNB1)/Wnt/β-catenin signaling pathway in some cases.

中文翻译：

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使用全外显子测序比较良性和恶性毛母细胞瘤。

恶性pilomatricoma（MP）是一种罕见的头发基质癌，文献中仅报道了少数病例。鉴于这种癌症的罕见性以及缺乏相关的遗传数据，除了在某些情况下涉及连环蛋白Beta 1（CTNNB1）/ Wnt /β-catenin信号通路以外，对分子病理生理学的性质了解甚少。