Glioblastoma is the most malignant form of astrocytoma. The purpose of this study was to analyze the genetic characteristics of primary and recurrent glioblastomas using targeted sequencing and investigate the differences in mutational profiles between the locations of tumor recurrence.

中文翻译：

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靶向基因组测序揭示了局部和远处复发性胶质母细胞瘤之间的不同进化模式。

胶质母细胞瘤是星形细胞瘤的最恶性形式。这项研究的目的是使用靶向测序分析原发性和复发性胶质母细胞瘤的遗传特征，并研究肿瘤复发部位之间突变谱的差异。