Nickel-Catalyzed Three-Component Reductive Alkylacylation of Electron-Deficient Activated Alkenes,Organic Letters

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Nickel-Catalyzed Three-Component Reductive Alkylacylation of Electron-Deficient Activated Alkenes
Organic Letters ( IF 4.9 ) Pub Date : 2020-10-29 , DOI: 10.1021/acs.orglett.0c03210
Lin Wang ₁ , Chuan Wang _{1,

2}

Affiliation

Herein, we present a nickel-catalyzed three-component reductive alkylacylation of electron-deficient activated alkenes with tertiary alkyl bromides and acid anhydrides. This method enables the efficient preparation of a variety of ketones with broad substrate scope and high functionality tolerance starting from simple precursors. On the basis of the preliminary mechanistic investigations, a catalytic cycle involving the synergistic interaction of nickel, zinc, and MgCl₂ is proposed as the major reaction pathway.

中文翻译：

缺电子活化烯烃的镍催化三组分还原烷基化

在本文中，我们提出了缺电子活化烯烃与叔烷基溴化物和酸酐的镍催化三组分还原烷基酰化反应。该方法能够从简单的前体开始有效制备具有广泛底物范围和高功能耐受性的各种酮。在初步的机理研究的基础上，提出了涉及镍，锌和MgCl ₂协同相互作用的催化循环作为主要反应途径。

更新日期：2020-11-21

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