Electron‐deficient half‐sandwich complexes are a class of under‐studied organometallics with demonstrated potential as metallodrug candidates. This study investigates the effect of two 16‐electron organoruthenium complexes ([(p‐cym)Ru(benzene‐1,2‐dithiolato)] (1) and [(p‐cym)Ru(maleonitriledithiolate)] (2)) on the cell viability of non‐immortalised human lymphocytes from healthy individuals. The genotoxic effects of 1 and 2 in lymphocytes are also investigated by using the Comet and cytokinesis‐block micronucleus assays. Gene expression studies were carried out on a panel of genes involved in apoptosis and the DNA damage‐repair response. Results show that the two 16‐electron complexes do not have significant effect on the cell viability of human lymphocytes from healthy individuals. However, an increase in DNA damage is induced by both compounds, presumably through oxidative stress production.

中文翻译：

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评估两种缺电子半夹心复合物对健康个体人类淋巴细胞的毒性

缺电子半夹心配合物是一类研究不足的有机金属化合物，具有作为候选金属药物的潜力。本研究调查了两种 16 电子有机钌配合物（[( p- cym)Ru(benzo-1,2-dithiolato)] ( 1 ) 和 [( p- cym)Ru(maleonitriledithiolate)] ( 2 )）对来自健康个体的非永生化人淋巴细胞的细胞活力。1和2的遗传毒性作用还通过使用彗星和胞质分裂阻断微核试验来研究淋巴细胞中的 对一组参与细胞凋亡和 DNA 损伤修复反应的基因进行了基因表达研究。结果表明，这两种 16 电子复合物对来自健康个体的人类淋巴细胞的细胞活力没有显着影响。然而，这两种化合物都会诱导 DNA 损伤的增加，这可能是通过氧化应激的产生。