There has been a longstanding debate about the role of folate in the etiology of orofacial clefts (OFCs). Studies of different measures of nutritional intake or folate status have been done to investigate the possible role of folate in the prevention of OFC. Only one knowledge synthesis has attempted to bring together different types of evidence. The aim of the present work was to update it.

中文翻译：

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叶酸摄入量，叶酸状态标记和口腔裂痕：一组更新的系统评价和荟萃分析

关于叶酸在口面部裂痕（OFCs）病因中的作用，存在着长期的争论。已经进行了各种营养摄入或叶酸状况的测量研究，以研究叶酸在预防OFC中的可能作用。只有一种知识综合试图将不同类型的证据汇集在一起​​。当前工作的目的是对其进行更新。