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Low-Dose Tramadol as an Off-Label Antidepressant: A Data Mining Analysis from the Patients’ Perspective
ACS Pharmacology & Translational Science ( IF 4.9 ) Pub Date : 2020-10-29 , DOI: 10.1021/acsptsci.0c00132 John A Bumpus 1
ACS Pharmacology & Translational Science ( IF 4.9 ) Pub Date : 2020-10-29 , DOI: 10.1021/acsptsci.0c00132 John A Bumpus 1
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Objectives: The purpose of this analysis was to assess, from the patients’ perspective, the effectiveness and relative safety of tramadol as an off-label antidepressant and to determine if patients’ views and experiences are consistent with the biomedical literature. Method: A data mining approach was used to analyze databases available at drugs.com. Results: Tramadol was reported to be an effective or very effective antidepressant by 94.6% of patients (123/130) who provided ratings submitted to User Reviews for Tramadol to Treat Depression (https://www.drugs.com/comments/tramadol/for-depression.html). When compared to 34 other antidepressants in the database titled Drugs Used to treat Depression (https://www.drugs.com/condition/depression.html), for which there were ≥100 individual reviews for each drug, tramadol was rated as being the most effective (effectiveness rating = 9.1/10). Phenelzine (effectiveness rating = 8.7/10) was the only other antidepressant having ≥100 individual reviews coupled with a very high (8.0–10.0) effectiveness rating. Eleven patients reported significant symptoms of withdrawal upon cessation of tramadol, and five patients reported loss or reduction of libido as a side effect. Most (57/72, 79.2%) patients who reported a dose consumed experienced relief from depression at low therapeutic doses (25–150 mg/day). Fourteen patients reported taking this antidepressant for 5–10 years, and four patients reported taking tramadol for 10 or more years. Results demonstrated that most patients’ comments and beliefs are consistent with the biomedical literature. Conclusions: Patients’ reviews coupled with a survey of the biomedical literature indicate that at low therapeutic doses in the absence of interactions with other drugs, adult patients found tramadol to be a generally safe, effective, and fast-acting medication for relief from depression.
中文翻译：
低剂量曲马多作为标签外抗抑郁药：从患者角度进行的数据挖掘分析
目的：本分析的目的是从患者的角度评估曲马多作为适应证外抗抑郁药的有效性和相对安全性，并确定患者的观点和经验是否与生物医学文献一致。方法：使用数据挖掘方法来分析 drug.com 上的数据库。结果： 94.6% 的患者 (123/130) 报告曲马多是一种有效或非常有效的抗抑郁药，这些患者提交了曲马多治疗抑郁症的用户评论(https://www.drugs.com/comments/tramadol/ for-depression.html）。与标题为“用于治疗抑郁症的药物” (https://www.drugs.com/condition/depression.html) 的数据库中的其他 34 种抗抑郁药相比，每种药物都有 ≥100 条单独的评论，曲马多被评为最有效（有效性评级 = 9.1/10）。苯乙肼（有效性评级 = 8.7/10）是唯一拥有 ≥100 条个人评价且有效性评级非常高（8.0–10.0）的其他抗抑郁药。 11 名患者报告在停止使用曲马多后出现明显的戒断症状，5 名患者报告副作用是性欲丧失或减少。大多数（57/72，79.2%）报告服用剂量的患者在低治疗剂量（25-150 毫克/天）下抑郁症得到缓解。 14 名患者报告服用这种抗抑郁药 5-10 年，4 名患者报告服用曲马多 10 年或更长时间。结果表明，大多数患者的评论和信念与生物医学文献一致。 结论：患者的评论以及生物医学文献的调查表明，在不与其他药物相互作用的情况下，在低治疗剂量下，成年患者发现曲马多通常是一种安全、有效且快速起效的缓解抑郁症的药物。
更新日期：2020-12-12
中文翻译：
低剂量曲马多作为标签外抗抑郁药：从患者角度进行的数据挖掘分析
目的：本分析的目的是从患者的角度评估曲马多作为适应证外抗抑郁药的有效性和相对安全性，并确定患者的观点和经验是否与生物医学文献一致。方法：使用数据挖掘方法来分析 drug.com 上的数据库。结果： 94.6% 的患者 (123/130) 报告曲马多是一种有效或非常有效的抗抑郁药，这些患者提交了曲马多治疗抑郁症的用户评论(https://www.drugs.com/comments/tramadol/ for-depression.html）。与标题为“用于治疗抑郁症的药物” (https://www.drugs.com/condition/depression.html) 的数据库中的其他 34 种抗抑郁药相比，每种药物都有 ≥100 条单独的评论，曲马多被评为最有效（有效性评级 = 9.1/10）。苯乙肼（有效性评级 = 8.7/10）是唯一拥有 ≥100 条个人评价且有效性评级非常高（8.0–10.0）的其他抗抑郁药。 11 名患者报告在停止使用曲马多后出现明显的戒断症状，5 名患者报告副作用是性欲丧失或减少。大多数（57/72，79.2%）报告服用剂量的患者在低治疗剂量（25-150 毫克/天）下抑郁症得到缓解。 14 名患者报告服用这种抗抑郁药 5-10 年，4 名患者报告服用曲马多 10 年或更长时间。结果表明，大多数患者的评论和信念与生物医学文献一致。 结论：患者的评论以及生物医学文献的调查表明，在不与其他药物相互作用的情况下，在低治疗剂量下，成年患者发现曲马多通常是一种安全、有效且快速起效的缓解抑郁症的药物。
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