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Clitoria ternatea Mediated Synthesis of Graphene Quantum Dots for the Treatment of Alzheimer’s Disease
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2020-10-29 , DOI: 10.1021/acschemneuro.0c00273 Kajal Tak 1 , Rekha Sharma 2 , Vivek Dave 1, 3 , Smita Jain 1 , Swapnil Sharma 1
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2020-10-29 , DOI: 10.1021/acschemneuro.0c00273 Kajal Tak 1 , Rekha Sharma 2 , Vivek Dave 1, 3 , Smita Jain 1 , Swapnil Sharma 1
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The main purpose of the present study was to synthesize graphene quantum dots (GQDs)from the flowers of Clitoria ternatea with the help of one-pot microwave-assisted green synthesis for the treatment of Alzheimer’s disease. Further, the synthesized graphene quantum dots show a particle size of 10 nm ±1.3, a PDI of 0.354 ± 1.8, and a ζ potential of −46 ± 0.4, indicating the good stability of the quantum dots. With the help of scanning electron microscopy (SEM) and transfer electron microscopy (TEM) examination, the surface microscopic behavior of the synthesized quantum dots was determined. The presence of functional groups in the quantum dots was determined by Fourier-transform infrared spectroscopy (FTIR) study, the chemical state information on the sample was determined with the help of X-ray photoelectron spectroscopy (XPS), and the surface area of the dots was determined with the help of a surface area analyzer. With the help of a radial arm maze and water morris maze assay, the learning and memory capacity of the quantum dots was assessed, and the results show that the ctGQDs significantly decreased the transfer latency to reach the baited arm in 10.37 ± 1.65 s or to the hidden platform in 18.42 ± 0.99 s in 7 days. The synthesized quantum dots show more inhibition of the acetyl cholinesterase enzyme, i.e., 86.32 ± 1.52%, as compared to that of pure donepezil, i.e., 72.46 ± 2.21%. ctGQDs considerably increased the level of glutathione and protein and decreased the level of lipid peroxide and nitric oxide. The histopathological image of ctGQDs shows more preservation of small pyramidal cell and treats the disorganization of the cells. These results suggest that the quantum dots significantly crossed the blood–brain barrier since they were small in size and were effective in reducing Alzheimer-like symptoms in rodents, and thus, it can be concluded that Clitoria ternatea flowers can be used as an adjuvant in the treatment of Alzheimer’s.
中文翻译：
Clitoria ternatea介导的石墨烯量子点合成治疗阿尔茨海默氏病
本研究的主要目的是从Clitoria ternatea的花中合成石墨烯量子点（GQD）。借助一锅微波辅助绿色合成技术来治疗阿尔茨海默氏病。此外，合成的石墨烯量子点显示出10nm±1.3的粒度，0.354±1.8的PDI和-46±0.4的ζ电势，表明量子点的良好稳定性。借助扫描电子显微镜（SEM）和转移电子显微镜（TEM）检查，确定了合成量子点的表面微观行为。通过傅里叶变换红外光谱（FTIR）研究确定了量子点中官能团的存在，借助X射线光电子能谱（XPS）确定了样品上的化学状态信息，并测定了其表面积。借助于表面积分析仪确定点。借助a臂迷宫和水莫里斯迷宫分析，评估了量子点的学习和记忆能力，结果表明，ctGQDs显着降低了在10.37±1.65 s或至隐藏平台在7天内在18.42±0.99 s内。合成的量子点显示出对乙酰胆碱酯酶的更多抑制作用，我。ê，86.32±1.52％，相比于纯的多奈哌齐的，我。e。，72.46±2.21％。ctGQD大大增加了谷胱甘肽和蛋白质的水平，并降低了脂质过氧化物和一氧化氮的水平。ctGQD的组织病理学图像显示出更多的小锥体细胞得以保存，并治疗了细胞的组织混乱。这些结果表明，量子点的体积很小，并且可以有效地减轻啮齿动物的阿尔茨海默氏样症状，因此量子点显着穿过了血脑屏障，因此可以得出结论，Clitoria ternatea花可以用作佐剂。阿尔茨海默氏症的治疗。
更新日期：2020-11-18
中文翻译：
Clitoria ternatea介导的石墨烯量子点合成治疗阿尔茨海默氏病
本研究的主要目的是从Clitoria ternatea的花中合成石墨烯量子点（GQD）。借助一锅微波辅助绿色合成技术来治疗阿尔茨海默氏病。此外，合成的石墨烯量子点显示出10nm±1.3的粒度，0.354±1.8的PDI和-46±0.4的ζ电势，表明量子点的良好稳定性。借助扫描电子显微镜（SEM）和转移电子显微镜（TEM）检查，确定了合成量子点的表面微观行为。通过傅里叶变换红外光谱（FTIR）研究确定了量子点中官能团的存在，借助X射线光电子能谱（XPS）确定了样品上的化学状态信息，并测定了其表面积。借助于表面积分析仪确定点。借助a臂迷宫和水莫里斯迷宫分析，评估了量子点的学习和记忆能力，结果表明，ctGQDs显着降低了在10.37±1.65 s或至隐藏平台在7天内在18.42±0.99 s内。合成的量子点显示出对乙酰胆碱酯酶的更多抑制作用，我。ê，86.32±1.52％，相比于纯的多奈哌齐的，我。e。，72.46±2.21％。ctGQD大大增加了谷胱甘肽和蛋白质的水平，并降低了脂质过氧化物和一氧化氮的水平。ctGQD的组织病理学图像显示出更多的小锥体细胞得以保存，并治疗了细胞的组织混乱。这些结果表明，量子点的体积很小，并且可以有效地减轻啮齿动物的阿尔茨海默氏样症状，因此量子点显着穿过了血脑屏障，因此可以得出结论，Clitoria ternatea花可以用作佐剂。阿尔茨海默氏症的治疗。
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