Organogermanes as Orthogonal Coupling Partners in Synthesis and Catalysis,Accounts of Chemical Research

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Organogermanes as Orthogonal Coupling Partners in Synthesis and Catalysis
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2020-10-29 , DOI: 10.1021/acs.accounts.0c00527
Christoph Fricke ₁ , Franziska Schoenebeck ₁

Affiliation

Since the advent of metal-catalyzed cross-coupling technology more than 40 years ago, the field has grown to be ever-increasingly enabling, yet the employed coupling partners are largely still those that were originally employed in the context of Pd-catalyzed cross-coupling, namely, arylboronic esters/acids, aryl silanes, aryl stannanes, or organometallic reagents (RMgX, RZnX). Aryl germanes have little precedent in the literature; they were historically explored in the context of Pd⁰/Pd^II-catalyzed cross-coupling reactions but were found to be much less reactive than the already established reagents. Consequently, few efforts were made by the community on their further mechanistic or synthetic exploration.

中文翻译：

有机锗烷在合成和催化中作为正交偶联伙伴

自40年前金属催化的交叉偶联技术问世以来，该领域已变得越来越强大，但所使用的偶联伙伴仍主要是最初在Pd催化的交叉偶联中使用的那些。偶合，即芳基硼酸酯/酸，芳基硅烷，芳基锡烷或有机金属试剂（RMgX，RZnX）。芳烃锗烷在文献中几乎没有先例。他们是在Pd ⁰ / Pd ^II催化的交叉偶联反应中进行历史探索的，但发现它们的反应性远低于已建立的试剂。因此，社区在其进一步的机械或综合探索上所做的努力很少。

更新日期：2020-11-17

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