We aimed to identify brain structural changes in cortical and subcortical regions linked to recent suicidal behavior. We performed secondary analyses of structural MRI data of two independent studies, namely the Establishing Moderators/Biosignatures of Antidepressant Response - Clinical Care (EMBARC) study and a Little Rock study on acute suicidal behavior. Study 1 (EMBARC, N = 187), compared individuals with remote suicide attempts (Remote-SA), individuals with lifetime suicide ideation but no attempts (Lifetime-SI only), and depressed individuals without lifetime suicide ideation or attempts (non-suicidal depressed). Study 2 (Little Rock data, N = 34) included patients recently hospitalized for suicide ideation or attempt constituted by: patients who recently attempted suicide (Recent-SA), individuals with remote suicide attempts (Remote-SA), and Lifetime-SI only. Study 3 combined the EMBARC and Little Rock datasets including Recent-SA, Remote-SA, Lifetime-SI only and non-suicidal depressed individuals. In Study 1 and Study 2, no significant differences were observed between groups. In Study 3, significantly lower middle temporal gyrus thickness, insular surface area, and thalamic volume and higher volume in the nucleus accumbens were observed in Recent-SA. This pattern of structural abnormalities may underlie pain and emotion dysregulation, which have been linked to the transition from suicidal thoughts to action.

中文翻译：

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检查近期自杀行为中的大脑结构变化

我们旨在确定与近期自杀行为相关的皮质和皮质下区域的大脑结构变化。我们对两项独立研究的结构 MRI 数据进行了二次分析，即建立抗抑郁反应的调节剂/生物特征 - 临床护理 (EMBARC) 研究和一项关于急性自杀行为的小石城研究。研究 1 (EMBARC, N = 187)，比较了有远程自杀企图的个体 (Remote-SA)、有终生自杀意念但没有企图的个体（仅终生 SI）和没有终生自杀意念或企图的抑郁个体（非自杀郁闷）。研究 2（Little Rock 数据，N = 34）包括最近因自杀意念或企图而住院的患者，其构成为：最近企图自杀的患者（Recent-SA）、有远程自杀企图的个体（Remote-SA）、仅限终身SI。研究 3 结合了 EMBARC 和小石城数据集，包括近期-SA、远程-SA、仅终身 SI 和非自杀性抑郁个体。在研究 1 和研究 2 中，组间未观察到显着差异。在研究 3 中，在最近-SA 中观察到显着降低的颞中回厚度、岛叶表面积和丘脑体积以及更高的伏核体积。这种结构异常模式可能是疼痛和情绪失调的基础，这与从自杀念头到行动的转变有关。在最近-SA 中观察到颞中回厚度、岛叶表面积和丘脑体积显着降低，伏隔核体积显着降低。这种结构异常模式可能是疼痛和情绪失调的基础，这与从自杀念头到行动的转变有关。在最近-SA 中观察到颞中回厚度、岛叶表面积和丘脑体积显着降低，伏隔核体积显着降低。这种结构异常模式可能是疼痛和情绪失调的基础，这与从自杀念头到行动的转变有关。