Abstract Altered hippocampal functioning is proposed to play a critical role in the development of schizophrenia-spectrum disorders. Previous resting state functional Magnetic Resonance Imaging (rs-fMRI) studies report disrupted hippocampal connectivity in patients with psychosis and in individuals with clinical high risk, yet hippocampal connectivity has not been investigated in people with high schizotypy traits. Here we used rs-fMRI to examine hippocampal connectivity in healthy people with low (LS, n = 23) and high levels (HS, n = 22) of schizotypal traits assessed using the Schizotypy Personality Questionnaire. Using a bilateral hippocampal seed region, we examined resting state functional connectivity (RSFC) between hippocampus and striatal, thalamic and prefrontal cortex regions of interest. Compared to LS, HS participants showed lower RSFC between hippocampus and striatum and between hippocampus and thalamus. Whilst the group effect of reduced hippocampal RSFC in striatal and thalamic regions was driven by total schizotypy scores, positive schizotypy subfactor scores were significantly positively correlated with hippocampus-caudate/thalamus RSFC. Group differences in RSFC were not observed between hippocampus and prefrontal cortex. These results demonstrate that subclinical schizotypal traits are associated with altered hippocampal connectivity in striatal and thalamic regions and provide further support that hippocampal dysconnectivity confers risk for schizophrenia spectrum disorders.

中文翻译：

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高度分裂型特征与海马静息状态功能连接性降低有关。

摘要 海马功能的改变被认为在精神分裂症谱系障碍的发展中起关键作用。先前的静息状态功能磁共振成像 (rs-fMRI) 研究报告称，精神病患者和临床高危个体的海马连接被破坏，但尚未对具有高度分裂型特征的人的海马连接进行研究。在这里，我们使用 rs-fMRI 来检查健康人的海马连接，这些人具有使用分裂型人格问卷评估的低（LS，n = 23）和高水平（HS，n = 22）的分裂型特征。使用双侧海马种子区域，我们检查了海马与感兴趣的纹状体、丘脑和前额叶皮层区域之间的静息状态功能连接 (RSFC)。与LS相比，HS 参与者在海马和纹状体之间以及海马和丘脑之间显示出较低的 RSFC。虽然纹状体和丘脑区域海马 RSFC 减少的组效应是由总分裂型分数驱动的，但阳性分裂型子因子分数与海马尾状核/丘脑 RSFC 显着正相关。在海马和前额叶皮层之间未观察到 RSFC 的组差异。这些结果表明，亚临床分裂型特征与纹状体和丘脑区域海马连接的改变有关，并进一步支持海马连接障碍会导致精神分裂症谱系障碍的风险。虽然纹状体和丘脑区域海马 RSFC 减少的组效应是由总分裂型分数驱动的，但阳性分裂型子因子分数与海马尾状核/丘脑 RSFC 显着正相关。在海马和前额叶皮层之间未观察到 RSFC 的组差异。这些结果表明，亚临床分裂型特征与纹状体和丘脑区域海马连接的改变有关，并进一步支持海马连接障碍会导致精神分裂症谱系障碍的风险。虽然纹状体和丘脑区域海马 RSFC 减少的组效应是由总分裂型分数驱动的，但阳性分裂型子因子分数与海马尾状核/丘脑 RSFC 显着正相关。在海马和前额叶皮层之间未观察到 RSFC 的组差异。这些结果表明，亚临床分裂型特征与纹状体和丘脑区域海马连接的改变有关，并进一步支持海马连接障碍会导致精神分裂症谱系障碍的风险。