This Perspective examines the status of large-scale cortical interfaces through the lens of potential applications to active implants for brain-machine interfaces. Examples of research and development in a still embryonic field are discussed from a neuroengineer’s perspective, touching on the design of scalable electrophysiological sensors with the ambition to access thousands of cortical points at near-cellular-level resolution. Important issues include microscale geometry of neural probes, design of implantable ultra-low-power electronics, implementation of high-data-rate wireless telemetry, and compatible device packaging—all requiring advanced solutions along a translational path for chronic human use.

本“透视图”通过潜在应用的镜头来检查大型皮质接口的状态，这些应用可能会应用于脑机接口的有源植入物。从神经工程师的角度讨论了静止胚胎领域的研究和开发实例，涉及可扩展的电生理传感器的设计，以接近细胞水平的分辨率访问数千个皮质点。重要问题包括神经探针的微尺度几何形状，可植入的超低功耗电子设备的设计，高数据速率无线遥测技术的实现以及兼容的设备包装，所有这些都需要沿平移路径发展的高级解决方案，以供长期使用。