Striatal dopamine transporter (DAT) uptake assessment through I123-Ioflupane Single-Pphoton Emission Computed Tomography (SPECT) provides valuable information about the dopaminergic denervation occurring in Parkinson's disease (PD). However, little is known about the clinical or biological relevance of extrastriatal DAT uptake in PD. Here, from the Parkinson's Progression Markers Initiative, we studied 623 participants (431 PD and 192 healthy controls) with available SPECT data. Even though striatal denervation was undoubtedly the imaging hallmark of PD, extrastriatal DAT uptake was also reduced in patients with PD. Topographically, widespread frontal but also temporal and posterior cortical regions showed lower DAT uptake in PD patients with respect to healthy controls. Importantly, a longitudinal voxelwise analysis confirmed an active one-year loss of extrastriatal DAT uptake within the PD group. Extrastriatal DAT uptake also correlated with the severity of motor symptoms, cognitive performance, and cerebrospinal fluid α-synuclein levels. In addition, we found an association between the Catechol-O-methyltransferase val158met genotype and extrastriatal DAT uptake. These results highlight the clinical and biological relevance of extrastriatal SPECT-DAT uptake in PD.

中文翻译：

---

纹状体外 SPECT-DAT 摄取与新发帕金森病的临床和生物学特征相关

通过 I123-碘氟烷单光子发射计算机断层扫描 (SPECT) 进行的纹状体多巴胺转运蛋白 (DAT) 摄取评估提供了有关帕金森病 (PD) 中发生的多巴胺能去神经支配的宝贵信息。然而，关于纹状体外 DAT 摄取在 PD 中的临床或生物学相关性知之甚少。在这里，从帕金森病进展标志物倡议，我们研究了 623 名参与者（431 名 PD 和 192 名健康对照者）和可用的 SPECT 数据。尽管纹状体去神经支配无疑是 PD 的成像标志，但 PD 患者的纹状体外 DAT 摄取也减少。在地形上，与健康对照相比，广泛的额叶以及颞叶和后皮质区域显示 PD 患者的 DAT 摄取较低。重要的，纵向体素分析证实了 PD 组中纹状体外 DAT 摄取的活跃一年损失。纹外 DAT 摄取还与运动症状的严重程度、认知能力和脑脊液 α-突触核蛋白水平相关。此外，我们发现儿茶酚-O-甲基转移酶 val158met 基因型与纹状体外 DAT 摄取之间存在关联。这些结果突出了纹状体外 SPECT-DAT 摄取在 PD 中的临床和生物学相关性。