Nano-targeting lessons from the SARS-CoV-2,Nano Today

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Nano-targeting lessons from the SARS-CoV-2
Nano Today ( IF 13.2 ) Pub Date : 2020-10-23 , DOI: 10.1016/j.nantod.2020.101012
I R S Ribeiro _{1,

2} , R F da Silva ₁ , C P Silveira ₁ , F E Galdino _{1,

2} , M B Cardoso _{1,

2}

Affiliation

The lack of targeting efficacy has frequently led functionalized nanoparticles to accumulate in unwanted cells and tissues while boosting toxicity-related effects. Conversely, viruses are natural nanoparticles that precisely and responsively interact with the biological machinery through an effective-driven fashion. This interaction is enhanced by a meticulous spatial arrangement which results in a quasi-crystalline distribution of proteins on the viruses’ surface. Amidst the COVID-19 pandemic, we propose to look at the SARS-CoV-2 nanoscale viral scaffold as an example of a highly-ordered architecture that must inspire and tailor the production of targeted synthetic nanoparticles.

中文翻译：

SARS-CoV-2 的纳米靶向教训

缺乏靶向功效经常导致功能化纳米颗粒在不需要的细胞和组织中积累，同时增强毒性相关效应。相反，病毒是天然的纳米粒子，通过有效驱动的方式与生物机器精确且灵敏地相互作用。这种相互作用通过细致的空间排列得到增强，从而导致病毒表面上蛋白质的准晶体分布。在 COVID-19 大流行期间，我们建议将 SARS-CoV-2 纳米级病毒支架视为高度有序的结构的一个例子，该结构必须激发和定制目标合成纳米颗粒的生产。

更新日期：2020-10-23

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