In this study, mesoporous silica SBA-15 particles were synthesized using poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) and tetraethoxysilane as the precursors and were subsequently modified with 3-aminopropyl triethoxysilane (APTES). The amine-functionalized particles were characterized using field-emission scanning electron microscopy, transmission electron microscopy, X-ray diffractometry, N₂ sorptiometry, Fourier-transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy, and thermogravimetric analysis. The prepared materials were subsequently used for the adsorption removal of small uremic toxins, namely urea, creatinine, and hippuric acid. The adsorption of these single toxins from synthetic serum samples on SBA-15–based adsorbents followed a pseudo-second-order kinetic model, and the adsorption was well described by the Langmuir isotherm. It was determined that the adsorption capacity of SBA-15 for urea and creatinine was increased after APTES functionalization. The highest adsorption capacities of SBA-15 modified with 0.2 mol/L APTES in toluene for urea and creatinine were 1644.7 and 181.7 mg/g, respectively, at 37 °C, whereas the highest adsorption capacity of pristine SBA-15 for hippuric acid was 111.7 mg/g. Preferential and competitive hydrogen bonding-promoted adsorption of urea over hippuric acid in binary mixtures occurred for the APTES-modified SBA-15 adsorbents, as demonstrated using the FTIR spectra of the adsorbents before and after adsorption.

-在本研究中，中孔二氧化硅SBA-15颗粒使用聚（乙二醇）合成块-聚（丙二醇） -嵌段-聚（乙二醇）和四乙氧基硅烷作为前体和随后用3-氨基丙基三乙氧基硅烷（APTES修饰的）。使用场发射扫描电子显微镜，透射电子显微镜，X射线衍射，N ₂表征胺官能化的颗粒剂量法，傅立叶变换红外光谱（FTIR），X射线光电子能谱和热重分析。所制备的材料随后用于吸附去除尿毒症小毒素，即尿素，肌酐和马尿酸。合成血清样品中这些单一毒素在基于SBA-15的吸附剂上的吸附遵循伪二级动力学模型，Langmuir等温线很好地描述了这种吸附。经确定，APTES功能化后，SBA-15对尿素和肌酐的吸附能力增加。在37°C下，用0.2 mol / L APTES改性的SBA-15在甲苯中对尿素和肌酐的最高吸附能力分别为1644.7和181.7 mg / g，而原始SBA-15对马尿酸的最高吸附能力为111.7毫克/克。