Abstract For decades, Drosophila gastrulation has been at the forefront of investigations into the molecular and cell biological principles by which tissues are formed and shaped into organs. Recent work has started to uncover how evolution shaped the elements and the processes of gastrulation during the early divergence of Drosophila and other flies. Here we look at the macroscopic processes that define fly gastrulation and how molecular patterning provides spatial instructions relevant for epithelial remodeling. We integrate studies of gastrulation in other flies to outline how epithelial morphogenesis changed over the course of fly evolution. This work exposes links between morphogenetic differences and changes in molecular patterning and signal transduction. We conclude with a discussion of how gastrulation can evolve through changes in the expression and regulation of patterning genes, or through changes in how such information is relayed to the cytoskeleton.

中文翻译：

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比较果蝇原肠胚形成：细胞生物学与胚胎形态发生进化之间的联系

摘要 几十年来，果蝇原肠胚形成一直处于研究分子和细胞生物学原理的前沿，通过这些原理，组织形成和塑造成器官。最近的工作已经开始揭示在果蝇和其他果蝇的早期分化过程中进化是如何塑造原肠胚形成的元素和过程的。在这里，我们看看定义苍蝇原肠胚形成的宏观过程以及分子模式如何提供与上皮重塑相关的空间指令。我们整合了其他果蝇的原肠胚形成研究，以概述果蝇进化过程中上皮形态发生的变化。这项工作揭示了形态发生差异与分子模式和信号转导变化之间的联系。