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Construction of long-circulation EpCAM targeted drug delivery system and its application in the diagnosis and treatment of breast cancer
Journal of Biomaterials Applications ( IF 2.3 ) Pub Date : 2020-10-20 , DOI: 10.1177/0885328220965135
Chao Song 1, 2 , Chao Gao 2 , Jing Zhao 2 , Zhenxin Wang 1
Affiliation  

Docetaxel (DOX) is usually one of drugs used for breast cancer treatment. The key of targeted drug delivery therapy is to deliver effective drugs directly and safely to the tumor focus via an efficient targeting drug carrier with immunogenicity. In this study, Long-circulating targeted drug carrying microspheres (DOX-PEG-EpCAM-MNs) entrapping DOX were constructed. In addition, both cytotoxicity and magnetic resonance imaging (MRI) analyses were performed to establish a mouse model and further complete corresponding performance analysis.The results showed that the average particle size of DOX-PEG-EpCAM-MNs was 139.3 ± 1.6 nm. Morphological analysis proves that they are spherical and uniformly dispersed. The Corresponding entrapment rate and drug carrying capacity are 82.43% and 7.16% respectively. Additionally, MRI shows that they have the capability to track tumor cells within 5 days. This study established a safe and efficient breast cancer cells targeted long-circulating drug delivery system.



中文翻译:

长循环EpCAM靶向给药系统的构建及其在乳腺癌诊治中的应用

多西他赛 (DOX) 通常是用于治疗乳腺癌的药物之一。靶向给药治疗的关键是通过具有免疫原性的高效靶向药物载体,将有效药物直接、安全地输送到肿瘤病灶。在这项研究中,构建了包埋 DOX 的长循环靶向载药微球 (DOX-PEG-EpCAM-MNs)。此外,还进行了细胞毒性和磁共振成像(MRI)分析,建立了小鼠模型,并进一步完成了相应的性能分析。结果表明,DOX-PEG-EpCAM-MNs的平均粒径为139.3±1.6 nm。形貌分析证明它们呈球形,分布均匀。相应的包封率和载药能力分别为82.43%和7.16%。此外,MRI显示他们有能力在5天内追踪肿瘤细胞。本研究建立了一种安全高效的乳腺癌细胞靶向长循环给药系统。

更新日期:2020-10-29
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