The Lush Prize supports animal-free testing by awarding money prizes of up to £350,000 per year to the most effective projects and individuals who have been working towards the goal of replacing animals in product or ingredient safety testing. Since its inception in 2012, the Lush Prize has distributed almost £2 million. Prizes are awarded for developments in five strategic areas: Science; Lobbying; Training; Public Awareness; and Young Researchers. In 2015, the judges also awarded a Black Box prize for the development of the skin sensitisation Adverse Outcome Pathway and its associated in vitro assays. The Science Prize is awarded to researchers whose work the judging panel believe to have made the most significant contribution, in the preceding year, to the replacement of animal testing. This 2018 Science Background paper outlines the research projects that were presented to the Prize judges as potential candidates for the 2018 Lush Science Prize award. To obtain an overview of developments in the field of animal replacement in toxicity research, recent work by the relevant scientific institutions and projects in this area, including the OECD, CAAT, ECVAM, UK NC3Rs, US Tox21 Programme, the ToxCast programme and EU-ToxRisk, was reviewed. Recent developments in toxicity testing research were investigated by searching the relevant literature. Abstracts from conferences focusing on animal replacement in toxicity testing that were held in the preceding 12 months, were also analysed, including those from the 2017 10th World Congress on Alternatives and Animals in the Life Sciences and the 2018 Society of Toxicology annual conference.

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2018 郁郁葱葱科学奖

Lush 奖通过每年向最有效的项目和个人颁发高达 350,000 英镑的奖金来支持无动物测试，这些项目和个人一直致力于在产品或成分安全测试中替代动物的目标。自 2012 年成立以来，Lush Prize 已分发了近 200 万英镑。奖项授予五个战略领域的发展：科学；游说；训练; 公共意识; 和青年研究人员。2015 年，评委还因皮肤致敏不良结局途径及其相关体外检测的开发而授予黑盒奖。科学奖授予评审小组认为在过去一年中对替代动物试验做出最重大贡献的研究人员。这份 2018 年科学背景论文概述了作为 2018 年 Lush 科学奖的潜在候选人提交给奖项评委的研究项目。为了全面了解毒性研究中动物替代领域的发展，相关科学机构和项目在该领域的近期工作，包括 OECD、CAAT、ECVAM、英国 NC3R、美国 Tox21 计划、ToxCast 计划和欧盟- ToxRisk，进行了审查。通过搜索相关文献调查了毒性试验研究的最新进展。还分析了过去 12 个月举行的侧重于毒性试验中动物替代的会议的摘要，包括 2017 年第 10 届世界生命科学替代品和动物大会和 2018 年毒理学会年会的摘要。