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Factors Affecting the Timing of a Central Line Associated Bloodstream Infection Onset in Children with Cancer
Journal of Pediatric Hematology/Oncology Nursing ( IF 1.0 ) Pub Date : 2020-10-26 , DOI: 10.1177/1043454220966831
Mina Park 1, 2 , Young-Mi Seo 3 , Yoon Jung Shin 1 , Jung Woo Han 1, 4 , Eunhee Cho 5 , Hyeju Jang 6
Affiliation  

Purpose: The purpose of this study is to identify controllable treatment-environment-related factors affecting the timing of a central line-associated bloodstream infection (CLABSI) onset in children with cancer with central venous catheters (CVC). Design: This study is a secondary data analysis with the data extracted from electronic medical records in a tertiary hospital in South Korea. This study was conducted by reviewing electronic medical records of 470 pediatric cancer patients younger than the age of 18 years from 2010 to 2016. Method: The timing of a CLABSI onset was identified through the onset of CLABSI and the duration of catheterization. Cox proportional hazards regression analysis was used to estimate the impact of variables on the timing of CLABSI onset. The duration of catheterization was estimated using the Kaplan–Meier method. Finding: Multivariable analysis by Cox proportional model analysis showed that there are six independent variables affecting the timing of a CLABSI onset: length of stay in hospital, catheter insertion location, use of antibiotics on day of catheter insertion, catheter function, number of blood transfusions per 100 days, and number of blood tests per 100 days. Conclusions: The findings of this study provide a foundation for the development of EBP-based CVC guidelines to effectively reduce CLABSIs and maintain a long-term CVC without a CLABSI.

中文翻译:

影响癌症患儿中线相关血流感染发病时间的因素

目的:本研究的目的是确定影响中心静脉导管 (CVC) 癌症患儿中心线相关血流感染 (CLABSI) 发病时间的可控治疗环境相关因素。设计:本研究是对韩国一家三级医院电子病历中提取的数据进行二次数据分析。本研究回顾了 2010 年至 2016 年 470 名 18 岁以下儿童癌症患者的电子病历。 方法:通过 CLABSI 的发病时间和导管插入术的持续时间确定 CLABSI 发病的时间。Cox 比例风险回归分析用于估计变量对 CLABSI 发病时间的影响。使用 Kaplan-Meier 方法估计导管插入的持续时间。发现:Cox 比例模型分析的多变量分析表明,有六个独立变量影响 CLABSI 发病的时间:住院时间、导管插入位置、导管插入当天抗生素的使用、导管功能、输血次数每 100 天,以及每 100 天的验血次数。结论:本研究的结果为制定基于 EBP 的 CVC 指南提供了基础,以有效减少 CLABSI 并在没有 CLABSI 的情况下维持长期 CVC。每 100 天的输血次数和每 100 天的血液检查次数。结论:本研究的结果为制定基于 EBP 的 CVC 指南提供了基础,以有效减少 CLABSI 并在没有 CLABSI 的情况下维持长期 CVC。每 100 天的输血次数和每 100 天的血液检查次数。结论:本研究的结果为制定基于 EBP 的 CVC 指南提供了基础,以有效减少 CLABSI 并在没有 CLABSI 的情况下维持长期 CVC。
更新日期:2020-10-26
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