Objective:

The present study aimed to examine the effects of SNAP25 on the integration ability of intrinsic brain functions in children with ADHD, and whether the integration ability was associated with working memory (WM).

Methods:

A sliding time window method was used to calculate the spatial and temporal concordance among five rs-fMRI regional indices in 55 children with ADHD and 20 healthy controls.

Results:

The SNAP25 exhibited significant interaction effects with ADHD diagnosis on the voxel-wise concordance in the right posterior central gyrus, fusiform gyrus and lingual gyrus. Specifically, for children with ADHD, G-carriers showed increased voxel-wise concordance in comparison to TT homozygotes in the right precentral gyrus, superior frontal gyrus, postcentral gyrus, and middle frontal gyrus. The voxel-wise concordance was also found to be related to WM.

Conclusion:

Our findings provided a new insight into the neural mechanisms of the brain function of ADHD children.

中文翻译：

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SNAP25对多动症儿童脑功能整合能力的影响

客观的：

本研究旨在检验SNAP25对 ADHD 儿童内在脑功能整合能力的影响，以及整合能力是否与工作记忆 (WM) 相关。

方法：

采用滑动时间窗法计算 55 名 ADHD 儿童和 20 名健康对照者的 5 个 rs-fMRI 区域指标的时空一致性。

结果：

SNAP25与 ADHD 诊断对右后中央回、梭状回和舌回的体素一致性表现出显着的交互作用。具体来说，对于患有 ADHD 的儿童，与右侧中央前回、额上回、中央后回和额中回的 TT 纯合子相比，G 携带者在体素方面表现出更高的一致性。体素方面的一致性也被发现与 WM 有关。

结论：

我们的研究结果为 ADHD 儿童脑功能的神经机制提供了新的见解。