Background

Cyclic hormonal fluctuations influence migraine incidence and severity. Previously, we described reduced menstrual cyclicity in estradiol levels and dermal blood flow reaction to capsaicin in female migraineurs. It is unclear whether pain perception in women with migraine is influenced by the menstrual cycle.

Methods

Women with menstrually-related migraine (n = 14), healthy age-matched controls (n = 10) and postmenopausal women (n = 15) were asked to grade trigeminal and non-trigeminal painful stimuli on a numeric pain rating scale on menstrual cycle day 19–21 (mid-luteal) and day 1–2 (early follicular).

Results

In women with menstrually-related migraine, trigeminal pain remained low throughout the cycle. Controls showed increased trigeminal pain during the mid-luteal phase compared to the early follicular phase. Changes throughout the cycle were significantly different between women with MRM and controls.

Conclusion

The compromised menstrual cyclicity of pain perception in women with menstrually-related migraine parallels our earlier findings on estradiol levels and dermal blood flow.

中文翻译：

---

与月经有关的偏头痛女性的疼痛感

背景

周期性荷尔蒙波动会影响偏头痛的发生率和严重程度。以前，我们描述了女性偏头痛患者的雌二醇水平和皮肤血流对辣椒素的反应降低的月经周期。目前尚不清楚偏头痛女性的痛觉是否受月经周期的影响。

方法

患有月经相关偏头痛的女性 (n = 14)、健康年龄匹配的对照组 (n = 10) 和绝经后女性 (n = 15) 被要求在月经周期的数字疼痛评分量表上对三叉神经和非三叉神经疼痛刺激进行分级第 19-21 天（黄体中期）和第 1-2 天（早期卵泡）。

结果

在患有月经相关偏头痛的女性中，三叉神经痛在整个周期中保持较低水平。与早期卵泡期相比，对照显示在黄体中期的三叉神经痛增加。整个周期的变化在 MRM 女性和对照组之间有显着差异。

结论

与月经相关的偏头痛女性痛觉的月经周期受到影响，这与我们早期对雌二醇水平和皮肤血流量的发现相似。