Tabernaesines A–I, Cytotoxic Aspidosperma–Aspidosperma-Type Bisindole Alkaloids from Tabernaemontana pachysiphon,Journal of Natural Products

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Tabernaesines A–I, Cytotoxic Aspidosperma–Aspidosperma-Type Bisindole Alkaloids from Tabernaemontana pachysiphon
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-10-28 , DOI: 10.1021/acs.jnatprod.9b00768
Wen-Fang Yi ₁ , Xiao Ding ₁ , Yuan-Zhi Chen ₁ , Tiwalade A Adelakun ₁ , Yu Zhang ₁ , Xiao-Jiang Hao ₁

Affiliation

Twenty-one aspidosperma–aspidosperma alkaloids, including the new tabernaesines A–J (1–9), were obtained from Tabernaemontana pachysiphon. The structures and absolute configurations were elucidated using HRMS and NMR experiments. Compounds 1–9 possessed a rare spiro heterocycle moiety between the monomeric units, while compounds 4 and 5 were characterized by an indole ring fused with an (N,N-diethyl)methyl amino group. Compounds 1, 5–7, 15, and 16 exhibited moderate cytotoxic potency against various human cancer cell lines at IC₅₀ 2.5–9.8 μM.

中文翻译：

Tabernaesines A–I，来自 Tabernaemontana pachysiphon 的细胞毒性 Aspidosperma-Aspidosperma-Type Bisindole 生物碱

二十一白坚木属-白坚木属生物碱，包括新的tabernaesines甲-J（1 - 9），为得自狗牙花属pachysiphon。使用 HRMS 和 NMR 实验阐明了结构和绝对构型。化合物1 - 9所具有的单体单元之间的稀有螺杂环部分，而化合物4和5是由与（稠合的吲哚环，其特征在于Ñ，ñ -二乙基）甲基氨基。化合物1，5 - 7，15，和16在 IC ₅₀ 2.5–9.8 μM 时对各种人类癌细胞系表现出中等的细胞毒性效力。

更新日期：2020-11-25

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