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Synthetic yeast brews neuroactive compounds
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2020-10-28 , DOI: 10.1038/s41589-020-00691-5
Yang Gu , Peng Xu

Metabolic engineering offers the flexibility to meet market demand for bioactive natural products but can be hampered when a necessary protein or intermediate is toxic. In yeast, modifying the subcellular localization of biosynthetic enzymes can alleviate toxicity and increase production titer.

中文翻译:

合成酵母酿造神经活性化合物

代谢工程学可以灵活满足市场对生物活性天然产物的需求,但当必需的蛋白质或中间体有毒时,可能会受到阻碍。在酵母中,修饰生物合成酶的亚细胞定位可以减轻毒性并提高生产效价。
更新日期:2020-10-29
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