Metabolic engineering offers the flexibility to meet market demand for bioactive natural products but can be hampered when a necessary protein or intermediate is toxic. In yeast, modifying the subcellular localization of biosynthetic enzymes can alleviate toxicity and increase production titer.

中文翻译：

---

合成酵母酿造神经活性化合物

代谢工程学可以灵活满足市场对生物活性天然产物的需求，但当必需的蛋白质或中间体有毒时，可能会受到阻碍。在酵母中，修饰生物合成酶的亚细胞定位可以减轻毒性并提高生产效价。