Design of a Bioinert Interface Using an Amphiphilic Block Copolymer Containing a Bottlebrush Unit of Oligo(oxazoline),ACS Applied Bio Materials

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Design of a Bioinert Interface Using an Amphiphilic Block Copolymer Containing a Bottlebrush Unit of Oligo(oxazoline)
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-10-28 , DOI: 10.1021/acsabm.0c01118
Jin-Hyeok Hong ₁ , Masayasu Totani ₁ , Daisuke Kawaguchi _{1,

2} , Hiroyasu Masunaga ₃ , Norifumi L Yamada ₄ , Hisao Matsuno _{1,

2,

5} , Keiji Tanaka _{1,

2,

5}

Affiliation

We designed an amphiphilic block copolymer, poly(methyl methacrylate)-block-poly[oligo(2-ethyl-2-oxazoline) methacrylate] (PMMA-b-P[O(Ox)MA]), suitable for bioinert coating. Angular-dependent X-ray photoelectron spectroscopy and neutron reflectivity measurements revealed that the outermost surface of a dried film of PMMA-b-P[O(Ox)MA] was covered with the PMMA block-rich layer. Once the film came into contact with water, the P[O(Ox)MA] bottlebrush block was segregated toward the water interface. This structural rearrangement in the outermost region of the film resulted in the formation of the swollen oligo(oxazoline) layer with excellent bioinertness in terms of the suppression of serum protein adsorption and NIH3T3 fibroblast adhesion.

中文翻译：

使用含有低聚（恶唑啉）瓶刷单元的两亲嵌段共聚物设计生物惰性界面

我们设计了一种适用于生物惰性涂层的两亲嵌段共聚物聚（甲基丙烯酸甲酯）-嵌段-聚[低聚（2-乙基-2-恶唑啉）甲基丙烯酸酯]（PMMA- b -P[O(Ox)MA]）。与角度相关的 X 射线光电子能谱和中子反射率测量表明， PMMA- b -P[O(Ox)MA] 干膜的最外表面覆盖有富含 PMMA 块的层。一旦薄膜与水接触，P[O(Ox)MA] 瓶刷块就会向水界面分离。薄膜最外层区域的这种结构重排导致形成肿胀的寡（恶唑啉）层，在抑制血清蛋白吸附和 NIH3T3 成纤维细胞粘附方面具有出色的生物惰性。

更新日期：2020-11-16

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