Novel Dioxane and Morpholino Nucleotide Analogues: Syntheses and RNA‐Hybridization Properties,ChemBioChem

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Novel Dioxane and Morpholino Nucleotide Analogues: Syntheses and RNA‐Hybridization Properties
ChemBioChem ( IF 2.6 ) Pub Date : 2020-10-28 , DOI: 10.1002/cbic.202000693
Armin Hofmeister ₁ , Kerstin Jahn-Hofmann ₁ , Arne Krack ₁ , Armin Müller ₁ , Michael Kurz ₁ , Sabine Scheidler ₁

Affiliation

Towards synthetic oligonucleotides: Starting from the 4’‐C‐hydroxymethyl‐modified ribose derivative (1), synthetic routes to two novel nucleoside analogues with dioxane and morpholine central scaffolds were developed and realized in two diastereomeric series. The final phosphoramidites were incorporated into an artificial RNA double strand, and the thermal stabilities were determined by melting temperature analysis.

中文翻译：

新型二恶烷和吗啉代核苷酸类似物：合成和 RNA 杂交特性

合成寡核苷酸：从 4' - C-羟甲基修饰的核糖衍生物 ( 1 ) 开始，开发了两种具有二恶烷和吗啉中心支架的新型核苷类似物的合成路线，并在两个非对映异构体系列中实现。最终的亚磷酰胺掺入人工RNA双链中，并通过熔解温度分析确定热稳定性。

更新日期：2020-10-28

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