Cover Feature: Towards Zwitterionic Oligonucleotides with Improved Properties: the NAA/LNA‐Gapmer Approach (ChemBioChem 22/2020),ChemBioChem

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Cover Feature: Towards Zwitterionic Oligonucleotides with Improved Properties: the NAA/LNA‐Gapmer Approach (ChemBioChem 22/2020)
ChemBioChem ( IF 2.6 ) Pub Date : 2020-10-28 , DOI: 10.1002/cbic.202000733
Melissa Wojtyniak ₁ , Boris Schmidtgall ₂ , Philine Kirsch ₁ , Christian Ducho _{1,

2}

Affiliation

The cover feature picture shows our work on a gapmer oligonucleotide with a zwitterionic backbone structure in the central gap and two anionic outer segments. One key question was if and how such a gapmer would bind to RNA, that is, if it displays sufficient binding affinity and base‐pairing fidelity. The other key question was if it would be stable towards nuclease‐mediated degradation. Our paper reports on the favourable properties of the zwitterionic gapmer oligonucleotide regarding these and further aspects. More information can be found in the full paper by C. Ducho et al.

中文翻译：

封面功能：改进特性的两性离子寡核苷酸：NAA / LNA-Gapmer方法（ChemBioChem 22/2020）

封面特征图片显示了我们在缝隙寡核苷酸上的工作，该寡核苷酸在中心缝隙中具有两性离子主链结构，并且具有两个阴离子外部链段。一个关键的问题是，这种缺口聚体是否以及如何与RNA结合，也就是说，它是否显示出足够的结合亲和力和碱基配对保真度。另一个关键问题是它是否对核酸酶介导的降解稳定。我们的论文报道了两性离子缺口聚体寡核苷酸在这些方面和其他方面的有利特性。有关更多信息，请参见C. Ducho等人的全文。

更新日期：2020-11-17

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