Dually localised proteins found in both the apicoplast and mitochondrion utilize the Golgi‐dependent pathway for apicoplast targeting in Toxoplasma gondii,Biology of the Cell

当前位置： X-MOL 学术 › Biol. Cell › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Dually localised proteins found in both the apicoplast and mitochondrion utilize the Golgi‐dependent pathway for apicoplast targeting in Toxoplasma gondii
Biology of the Cell ( IF 2.4 ) Pub Date : 2020-11-23 , DOI: 10.1111/boc.202000050
Aparna Prasad ₁ , Pragati Mastud ₁ , Swati Patankar ₁

Affiliation

Like other apicomplexan parasites, Toxoplasma gondii harbours a four‐membraned endosymbiotic organelle – the apicoplast. Apicoplast proteins are nuclear encoded and trafficked to the organelle through the endoplasmic reticulum (ER). From the ER to the apicoplast, two distinct protein trafficking pathways can be used. One such pathway is the cell's secretory pathway involving the Golgi, whereas the other is a unique Golgi‐independent pathway. Using different experimental approaches, many apicoplast proteins have been shown to utilize the Golgi‐independent pathway, whereas a handful of reports show that a few proteins use the Golgi‐dependent pathway. This has led to an emphasis towards the unique Golgi‐independent pathway when apicoplast protein trafficking is discussed in the literature. Additionally, the molecular features that drive proteins to each pathway are not known.

中文翻译：

在顶质体和线粒体中发现的双重定位蛋白利用高尔基体依赖途径在弓形虫中靶向顶质体

与其他顶端复合体寄生虫一样，弓形虫具有四膜内共生细胞器——顶端质体。顶质体蛋白由核编码并通过内质网 (ER) 运输到细胞器。从 ER 到顶质体，可以使用两种不同的蛋白质运输途径。一种这样的途径是涉及高尔基体的细胞分泌途径，而另一种是独特的不依赖高尔基体的途径。使用不同的实验方法，许多顶质体蛋白已被证明利用高尔基体非依赖性途径，而少数报告表明少数蛋白质使用高尔基体依赖性途径。当在文献中讨论顶质体蛋白运输时，这导致了对独特的高尔基体独立途径的强调。此外，

更新日期：2020-11-23

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11