Microrobots for targeted drug delivery are of great interest due to their minimal invasiveness and wireless controllability. Here, a magnetically driven porous degradable microrobot (PDM) is reported that consists of a 3D printed helical soft polymeric chassis made of a poly(ethylene glycol) diacrylate and pentaerythritol triacrylate matrix containing magnetite nanoparticles and the anticancer drug 5‐fluorouracil (5‐FU). The encapsulated Fe₃O₄ nanoparticles render the PDM a precise wireless magnetic actuation by means of rotating magnetic fields (RMFs). The increased surface area of the porous PDM facilitates the acoustically induced drug release due to a higher response to the acoustic energy. The drug release profile from the PDM can be selected on command from three different modes, referred to herein as natural, burst, and constant, by differentiating the ultrasound exposure condition. Finally, in vitro test results reveal different therapeutic results for each release mode. The observed great reduction of cancer cell viability in the burst‐ and constant‐release modes confirms that ultrasound with the proposed PDM can enhance the therapeutic effect by increasing drug concentration and sonoporation.

中文翻译：

---

可降解 3D 多孔磁性微型机器人的声学控制药物释放和靶向治疗

用于靶向给药的微型机器人因其微创性和无线可控性而备受关注。在这里，据报道磁驱动多孔可降解微型机器人 (PDM) 由 3D 打印的螺旋软聚合物底盘组成，该底盘由聚乙二醇二丙烯酸酯和季戊四醇三丙烯酸酯基质制成，其中含有磁铁矿纳米颗粒和抗癌药物 5-氟尿嘧啶 (5-FU) ）。封装的 Fe ₃ O ₄纳米粒子通过旋转磁场 (RMF) 使 PDM 成为精确的无线磁驱动。由于对声能的更高响应，多孔 PDM 增加的表面积促进了声诱导的药物释放。通过区分超声暴露条件，可以根据命令从三种不同模式中选择来自 PDM 的药物释放曲线，在此称为自然、突发和恒定模式。最后，体外测试结果揭示了每种释放模式的不同治疗结果。在突释和持续释放模式下观察到的癌细胞活力显着降低，证实了具有所提出的 PDM 的超声可以通过增加药物浓度和声孔效应来增强治疗效果。