Fumonisin toxins are produced by Fusarium fungal pathogens. Fumonisins are structural analogs of sphingosine and potent inhibitors of ceramide synthases (CerSs); they disrupt sphingolipid metabolism and cause disease in plants and animals. Over the past three decades, researchers have used fumonisin B1 (FB1), the most common fumonisin, as a probe to investigate sphingolipid metabolism in yeast and animals. Although the physiological effects of FB1 in plants have yet to be investigated in detail, forward and reverse genetic approaches have revealed many genes involved in these processes. In this review, we discuss the intricate network of signaling pathways affected by FB1, including changes in sphingolipid metabolism and the effects of these changes, with a focus on our current understanding of the multiple effects of FB1 on plant cell death and plant growth. We analyze the major findings that highlight the connections between sphingolipid metabolism and FB1-induced signaling, and we point out where additional research is needed to fill the gaps in our understanding of FB1-induced signaling pathways in plants.

伏马毒素毒素是由 镰刀菌真菌病原体。伏马菌素是鞘氨醇的结构类似物，是神经酰胺合酶（CerSs）的有效抑制剂。它们破坏鞘脂的代谢并导致动植物疾病。在过去的三十年中，研究人员使用最常见的伏马菌素伏马菌素B1（FB1）作为研究酵母和动物中鞘脂代谢的探针。尽管尚未详细研究FB1在植物中的生理作用，但正向和反向遗传方法已经揭示了许多与这些过程有关的基因。在这篇综述中，我们讨论了受FB1影响的复杂信号通路网络，包括鞘脂代谢的变化以及这些变化的影响，重点是我们目前对FB1对植物细胞死亡和植物生长的多重影响的理解。