Two new lignans, 3,4-(10-methoxy-phenylallyl)-9″-((10'-isopropanol-3',4'-furan)-phenylacetyl)-8″-dioxane-7″-O-β-d-glucopyranoside (1), 3,4-benzolactone-9″-((12'-isopropanol-3',4'-furan)-phenylbutenone)-8″-dioxane-7″-O-β-d-glucopyranoside (2), and nine known lignan derivatives (3-11) were isolated from the flower buds of Magnolia biondii Pamp. for the first time. Their structures were elucidated by 1D and 2D NMR, UV, IR, and MS data, as well as by comparison with those of the references. Compounds (1-11) were evaluated for their neuroprotective activities against 6-OHDA-induced cell death in SH-SY5Y cells. As a result, compounds 1, 2, and 5 exhibited significant neuroprotective activities with IC50 values in the range of 3.08-6.12 μM.

中文翻译：

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木兰花蕾木脂素的结构阐明和神经保护活性。

两种新型木脂素，3,4-(10-甲氧基-苯基烯丙基)-9″-((10'-异丙醇-3',4'-呋喃)-苯乙酰基)-8″-二恶烷-7″-O-β- d-吡喃葡萄糖苷 (1), 3,4-benzolactone-9"-((12'-isopropanol-3',4'-furan)-phenylbutenone)-8"-dioxane-7"-O-β-d-glucopyranoside (2) 和九种已知的木脂素衍生物 (3-11) 从 Magnolia biondii Pamp 的花蕾中分离出来。首次。它们的结构通过一维和二维核磁共振、紫外、红外和质谱数据以及与参考文献的比较来阐明。评价化合物(1-11)对SH-SY5Y细胞中6-OHDA诱导的细胞死亡的神经保护活性。结果，化合物 1、2 和 5 表现出显着的神经保护活性，IC50 值范围为 3.08-6.12 μM。