Abstract Emerging bacterial resistance is causing widespread problems for the treatment of various infections. Therefore, the search for antimicrobials is a never-ending task. Hydrazones and quinolines possess a wide variety of biological activities. Herewith, eleven quinoline hydrazone derivatives have been designed, synthesized, characterized and evaluated for their antibacterial activity and antitubercular potential against Mtb WT H37Rv. Compounds QH-02, QH-04 and QH-05 were found to be promising compounds with an MIC value of 4 μg/mL against Mtb WT H37Rv. Compounds QH-02, QH-04, QH-05, and QH-11 were also found to be active against bacterial strains including Acinetobacter baumanii, Escherichia coli and Staphylococcus aureus. Further, we have carried out experiments to confirm the cytotoxicity of the active compounds and found them to be non-toxic.

中文翻译：

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喹啉腙杂种抗菌抗结核活性的设计、合成与研究

摘要 新出现的细菌耐药性给各种感染的治疗带来了广泛的问题。因此，寻找抗菌药物是一项永无止境的任务。腙和喹啉具有多种生物活性。因此，已经设计、合成、表征和评估了 11 种喹啉腙衍生物的抗菌活性和对 Mtb WT H37Rv 的抗结核潜力。发现化合物 QH-02、QH-04 和 QH-05 是有前途的化合物，对 Mtb WT H37Rv 的 MIC 值为 4 μg/mL。还发现化合物 QH-02、QH-04、QH-05 和 QH-11 对包括鲍曼不动杆菌、大肠杆菌和金黄色葡萄球菌在内的细菌菌株具有活性。更多，