Bacteriocins are antimicrobial peptides some of which are endowed with antiviral, anticancer and antibiofilm properties. These properties could be improved through synergistic interactions of these bacteriocins with other bioactive molecules such as antibiotics, phages, nanoparticles and essential oils. A number of studies are steadily reporting the effects of these combinations as new and potential therapeutic strategies in the future, as they may offer many incentives over existing therapies. In particular, bacteriocins can benefit from combination with nanoparticles which can improve their stability and solubility, and protect them from enzymatic degradation, reduce their interactions with other molecules and improve their bioavailability. Furthermore, the combination of bacteriocins with other antimicrobials is foreseen as a way to reduce the development of antibiotic resistance due to the involvement of several modes of action. Another relevant advantage of these synergistic combinations is that it decreases the concentration of each antimicrobial component, thereby reducing their side effects such as their toxicity. In addition, combination can extend the utility of bacteriocins as antiviral or anticancer agents. Thus, in this review, we report and discuss the synergistic effects of bacteriocin combinations as medicines, and also for other diverse applications including, antiviral, antispoilage, anticancer and antibiofilms.

中文翻译：

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通过与生物活性物质的联系来扩大和增强细菌素的活性

细菌素是抗微生物肽，其中一些具有抗病毒，抗癌和抗生物膜特性。这些细菌素与其他生物活性分子（如抗生素，噬菌体，纳米颗粒和精油）的协同相互作用可以改善这些特性。许多研究稳定地报告了这些组合的效果，作为将来的新的和潜在的治疗策略，因为它们可能对现有疗法提供许多诱因。特别地，细菌素可从与纳米颗粒的结合中受益，所述纳米颗粒可改善其稳定性和溶解性，并保护其免于酶促降解，减少其与其他分子的相互作用并提高其生物利用度。此外，由于多种作用方式的参与，细菌素与其他抗微生物药的组合被认为是减少抗生素耐药性发展的一种方式。这些协同组合的另一个相关优点是，它降低了每种抗菌成分的浓度，从而降低了其副作用，例如毒性。另外，组合可以扩展细菌素作为抗病毒剂或抗癌剂的效用。因此，在这篇综述中，我们报告并讨论了细菌素组合作为药物的协同作用，以及对其他多种应用的协同作用，包括抗病毒，抗腐败，抗癌和抗生物膜。这些协同组合的另一个相关优点是，它降低了每种抗菌成分的浓度，从而降低了其副作用，例如毒性。另外，组合可以扩展细菌素作为抗病毒剂或抗癌剂的效用。因此，在这篇综述中，我们报告并讨论了细菌素组合作为药物的协同作用，以及对其他多种应用的协同作用，包括抗病毒，防腐败，抗癌和抗生物膜。这些协同组合的另一个相关优点是，它降低了每种抗菌成分的浓度，从而降低了其副作用，例如毒性。另外，组合可以扩展细菌素作为抗病毒剂或抗癌剂的效用。因此，在这篇综述中，我们报告并讨论了细菌素组合作为药物的协同作用，以及对其他多种应用的协同作用，包括抗病毒，抗腐败，抗癌和抗生物膜。