Postural orthostatic tachycardia syndrome (POTS) negatively impacts quality of life. The excessive increase in cardiac sympathetic modulation during standing, which characterizes POTS patients, leads to many symptoms and signs of orthostatic intolerance. Little is known about the consequences of the disease on work performance and its relationship with individual autonomic profiles. Twenty-two POTS patients regularly engaged in working activity (20 females, age 36 ± 12 years) and 18 gender- and age-matched controls underwent a clinical evaluation and filled out the Work Ability Index (WAI) questionnaire. POTS patients completed the Composite Autonomic Symptom Score (COMPASS31) questionnaire, underwent continuous electrocardiogram, blood pressure and respiratory activity recordings while supine and during a 75° head-up tilt (HUT). A power spectrum analysis provided the index of cardiac sympatho-vagal balance (LF/HF). WAI scores were significantly reduced in POTS patients (29.84 ± 1.40) compared to controls (45.63 ± 0.53, p < 0.01). A significant inverse correlation was found between individual WAI and COMPASS31 scores (r = −0.46; p = 0.03), HUT increase in heart rate (r = −0.57; p = 0.01) and LF/HF (r = −0.55; p = 0.01). In POTS patients, the WAI scores were inversely correlated to the intensity of autonomic symptoms and to the excessive cardiac sympathetic activation induced by the gravitational stimulus.

中文翻译：

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体位性体位性心动过速综合征的工作能力评估及其与心血管自主神经的关系

体位性体位性心动过速综合征（POTS）对生活质量产生负面影响。POTS患者的特征是站立时心脏交感神经调节过度增加，导致体位不耐症的许多症状和体征。关于该疾病对工作绩效的影响及其与个体自主性的关系知之甚少。定期从事工作活动的22名POTS患者（20名女性，年龄36±12岁）和18名性别和年龄匹配的对照组接受了临床评估，并填写了工作能力指数（WAI）问卷。POTS患者完成了复合自主神经症状评分（COMPASS31）问卷，在仰卧时和75°抬头向上（HUT）期间进行连续心电图，血压和呼吸活动记录。功率谱分析提供了心脏交感迷走神经平衡指数（LF / HF）。与对照组（45.63±0.53，p <0.01）相比，POTS患者的WAI得分显着降低（29.84±1.40）。在各个WAI和COMPASS31得分之间（r = -0.46; p = 0.03），HUT心率增加（r = -0.57; p = 0.01）和LF / HF（r = -0.55; p = 0.01）。在POTS患者中，WAI得分与自主神经症状强度和重力刺激引起的过度心脏交感神经活动呈负相关。在各个WAI和COMPASS31得分之间（r = -0.46; p = 0.03），HUT心率增加（r = -0.57; p = 0.01）和LF / HF（r = -0.55; p = 0.01）。在POTS患者中，WAI得分与自主神经症状强度和重力刺激引起的过度心脏交感神经活动呈负相关。在各个WAI和COMPASS31得分之间（r = -0.46; p = 0.03），HUT心率增加（r = -0.57; p = 0.01）和LF / HF（r = -0.55; p = 0.01）。在POTS患者中，WAI得分与自主神经症状强度和重力刺激引起的过度心脏交感神经活动呈负相关。