Several studies have found maternal exposure to particulate matter pollution was associated with adverse birth outcomes, including infant mortality and preterm birth. In this context, our study aims to quantify the air pollution burden of disease due to preterm birth complications and infant death in Paris, with particular attention to people living in the most deprived census blocks. Data on infant death and preterm birth was available from the birth and death certificates. The postal address of mother’s newborn was converted in census block number. A socioeconomic deprivation index was built at the census block level. Average annual ambient concentrations of PM₁₀ were modelled at census block level using the ESMERALDA atmospheric modelling system. The number of infant deaths attributed to PM₁₀ exposure is expressed in years of life lost. We used a three-step compartmental model to appraise neurodevelopmental impairment among survivors of preterm birth. We estimated that 12.8 infant deaths per 100,000 live births may be attributable to PM₁₀ exposure, and about one third of these infants lived in deprived census blocks. In addition, we found that approximately 4.8% of preterm births could be attributable to PM₁₀ exposure, and approximately 1.9% of these infants died (corresponding to about 5.75 deaths per 100,000 live birth). Quantification of environmental hazard-related health impacts for children at local level is essential to prioritizing interventions. Our study suggests that additional effort is needed to reduce the risk of complications and deaths related to air pollution exposure, especially among preterm births. Because of widespread exposure to air pollution, significant health benefits could be achieved through regulatory interventions aimed at reducing exposure of the population as a whole, and particularly of the most vulnerable, such as children and pregnant women.

中文翻译：

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使用伤残调整生命年（DALYs）测量巴黎早产并发症和婴儿死亡导致的空气污染引起的疾病负担

几项研究发现，孕妇暴露于颗粒物污染与不良的出生结局有关，包括婴儿死亡率和早产。在此背景下，我们的研究旨在量化因早产并发症和巴黎婴儿死亡而造成的空气污染负担，尤其要关注生活在最贫困人口普查区的人们。婴儿死亡和早产的数据可从出生和死亡证明中获得。母亲的新生儿的邮政地址已转换为人口普查区号。在人口普查区一级建立了社会经济剥夺指数。使用ESMERALDA大气建模系统在人口普查区级对PM _10的年平均环境浓度进行了建模。归因于PM ₁₀的婴儿死亡人数暴露以失去的生命数表示。我们使用三步间隔模型评估早产幸存者的神经发育障碍。我们估计每10万活产婴儿中有12.8例婴儿死亡可能归因于PM ₁₀暴露，其中约三分之一的婴儿生活在贫困的人口普查区。此外，我们发现大约4.8％的早产可归因于PM ₁₀暴露，约有1.9％的婴儿死亡（相当于每100,000例活产中约5.75例死亡）。量化对当地儿童的环境危害相关健康影响对于确定干预措施的优先级至关重要。我们的研究表明，需要采取更多的措施来减少与空气污染有关的并发症和死亡的风险，尤其是早产儿。由于广泛暴露于空气污染中，可以通过旨在减少整个人口，特别是最弱势群体（例如儿童和孕妇）的暴露的监管干预措施，来获得重大的健康益处。