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Ganoweberianones A and B, Antimalarial Lanostane Dimers from Cultivated Fruiting Bodies of the Basidiomycete Ganoderma weberianum
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-10-27 , DOI: 10.1021/acs.jnatprod.0c00879 Masahiko Isaka 1 , Panida Chinthanom 1 , Vanicha Vichai 1 , Sujinda Sommai 1 , Rattaket Choeyklin 2
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-10-27 , DOI: 10.1021/acs.jnatprod.0c00879 Masahiko Isaka 1 , Panida Chinthanom 1 , Vanicha Vichai 1 , Sujinda Sommai 1 , Rattaket Choeyklin 2
Affiliation
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Two lanostane dimers, ganoweberianones A (1) and B (2), together with seven previously undescribed lanostanes, ganoweberianic acids A–G (3–9), and three known compounds (10–12), were isolated from the artificially cultivated fruiting bodies of the basidiomycete Ganoderma weberianum. Ganoweberianone A (1) exhibited significant antimalarial activity against Plasmodium falciparum K1 (multidrug-resistant strain) with an IC50 value of 0.050 μM. A method for semisynthesis of 1 by condensation of the corresponding lanostane monomers and acid-catalyzed intramolecular transesterification was demonstrated.
中文翻译：
Ganoweberianones A 和 B，来自担子菌 Ganoderma weberianum 培养子实体的抗疟羊毛脂烷二聚体
从人工栽培的果实中分离出两种羊毛脂二聚体，灵芝酮 A ( 1 ) 和 B ( 2 )，以及七种先前未描述的羊毛脂，灵芝酸 A–G ( 3 – 9 ) 和三种已知化合物 ( 10 – 12 )担子菌Ganoderma weberianum 的尸体。Ganoweberianone A ( 1 ) 对恶性疟原虫K1（多重耐药菌株）表现出显着的抗疟活性，IC 50值为 0.050 μM。一种用于半合成方法1 通过相应羊毛脂烷单体的缩合和酸催化的分子内酯交换反应得到了证明。
更新日期：2020-11-25
中文翻译：
Ganoweberianones A 和 B，来自担子菌 Ganoderma weberianum 培养子实体的抗疟羊毛脂烷二聚体
从人工栽培的果实中分离出两种羊毛脂二聚体，灵芝酮 A ( 1 ) 和 B ( 2 )，以及七种先前未描述的羊毛脂，灵芝酸 A–G ( 3 – 9 ) 和三种已知化合物 ( 10 – 12 )担子菌Ganoderma weberianum 的尸体。Ganoweberianone A ( 1 ) 对恶性疟原虫K1（多重耐药菌株）表现出显着的抗疟活性，IC 50值为 0.050 μM。一种用于半合成方法1 通过相应羊毛脂烷单体的缩合和酸催化的分子内酯交换反应得到了证明。
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