Poly(lactic-co-glycolic acid) Nanoparticles as Delivery Systems for the Improved Administration of Radiotherapeutic Anticancer Agents,ACS Applied Nano Materials

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Poly(lactic-co-glycolic acid) Nanoparticles as Delivery Systems for the Improved Administration of Radiotherapeutic Anticancer Agents
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2020-10-27 , DOI: 10.1021/acsanm.0c02350
Michael W. Ambrogio ₁ , Miguel Toro-González ₁ , Tamara J. Keever ₁ , Timothy E. McKnight ₁ , Sandra M. Davern ₁

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This letter reports the development of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) as delivery systems that could potentially encapsulate and improve the administration of radiotherapeutic anticancer agents. Different metal ions (Ba, Gd, and Ce) were used as surrogates of α-emitting radionuclides (²²³Ra, ²²⁵Ac, and ²²⁷Th), and their encapsulation within the PLGA NPs (D_h < 300 nm) was evaluated. The initial concentration of metal ions, the metal salt (nitrate vs chloride), and the presence of chelators influenced the concentration of surrogate ions within the PLGA NPs. This letter shows the potential of PLGA NPs to encapsulate radionuclides, particularly α-emitters, for their application in nuclear medicine.

中文翻译：

聚（乳酸-共-glycolic酸）纳米粒子作为输送系统的放射治疗抗癌药物的改进的管理

此信报告聚的发展（乳酸-共（PLGA）纳米颗粒（NP）-glycolic酸）作为递送系统可能潜在地封装和提高放射治疗的抗癌剂的给药。使用不同的金属离子（Ba，Gd和Ce）作为发射α的放射性核素（²²³ Ra，²²⁵ Ac和²²⁷ Th）的替代物，并将其封装在PLGA NP中（D _h评估<300 nm）。金属离子的初始浓度，金属盐（硝酸盐对氯离子）和螯合剂的存在影响了PLGA NPs中替代离子的浓度。这封信显示了PLGA NP包封放射性核素（特别是α-发射体）在核医学中的应用的潜力。

更新日期：2020-11-25

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