RNA editing by ADAR1 destabilizes epigenetic-treatment-induced retrotransposon stem–loops and thus dampens the immune response to the treatment, suggesting that ADAR1 could be a therapeutic target in combination with epigenetic therapy.

中文翻译：

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没有 ADAR1 的癌症治疗成功的关键

ADAR1 的 RNA 编辑破坏了表观遗传治疗诱导的反转录转座子茎环的稳定性，从而抑制了对治疗的免疫反应，表明 ADAR1 可能成为与表观遗传治疗相结合的治疗靶点。