Recent advances in microfluidic techniques have enabled researchers to study sensitivities to immune checkpoint therapy, to determine patients’ response to particular antibody treatment. Utilization of this technology is helpful in antibody discovery and in the design of personalized medicine. A variety of microfluidic approaches can provide several functions in processes such as immunologic, genomic, and/or transcriptomic analysis with the aim of improving the efficacy and coverage of immunotherapy, particularly immune checkpoint blockade (ICB). To achieve this requires researchers to overcome the challenges in the current state of the technology. This review looks into the advancements in microfluidic technologies applied to researches on immune checkpoint blockade treatment and its potential shift from proof-of-principle stage to clinical application.

微流体技术的最新进展使研究人员能够研究免疫检查点治疗的敏感性，以确定患者对特定抗体治疗的反应。利用这项技术有助于抗体发现和个性化医疗的设计。各种微流体方法可以在免疫学、基因组学和/或转录组学分析等过程中提供多种功能，目的是提高免疫疗法的疗效和覆盖率，尤其是免疫检查点阻断 (ICB)。要实现这一目标，需要研究人员克服当前技术状态下的挑战。