Key Points IL-7Rαlow EM CD8+ T cells are anergy-like cells in vivo. IL-7Rαlow EM CD8+ T cells are defective in aerobic glycolysis. Visual Abstract Effector memory (EM) CD8+ T cells expressing lower levels of IL-7R α (IL-7Rαlow) from healthy individuals are partly compromised in vitro, but the identity of these cells has remained unclear. In this study, we demonstrate that human IL-7Rαlow EM CD8+ T cells are naturally occurring anergic cells in vivo and impaired in proliferation and IL-2 production but competent in IFN-γ and TNF-α production, a state that can be restored by IL-2 stimulation. IL-7Rαlow EM CD8+ T cells show decreased expression of GATA3 and c-MYC and are defective in metabolic reprogramming toward glycolysis, a process required for the proliferation of T cells. However, IL-7Rαlow EM CD8+ T cells can proliferate with TCR stimulation in the presence of IL-2 and IL-15, suggesting that these cells can be restored to normality or increased activity by inflammatory conditions and may serve as a reservoir for functional immunity.

中文翻译：

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来自健康个体的 IL-7Rαlow CD8+ T 细胞因糖酵解缺陷而无反应

关键点 IL-7Rαlow EM CD8+ T 细胞在体内是无反应样细胞。IL-7Rαlow EM CD8+ T 细胞在有氧糖酵解中存在缺陷。来自健康个体的表达较低水平 IL-7R α (IL-7Rαlow) 的视觉抽象效应记忆 (EM) CD8+ T 细胞在体外部分受损，但这些细胞的身份仍不清楚。在本研究中，我们证明人 IL-7Rαlow EM CD8+ T 细胞是体内天然存在的无能细胞，增殖和 IL-2 产生受损，但有能力产生 IFN-γ 和 TNF-α，这种状态可以通过IL-2 刺激。IL-7Rαlow EM CD8+ T 细胞显示 GATA3 和 c-MYC 表达降低，并且在代谢重编程向糖酵解方面存在缺陷，糖酵解是 T 细胞增殖所需的过程。然而，