Russian sheep breeds represent an important economic asset by providing meat and wool, whilst being adapted to extreme climates. By resequencing two Russian breeds from Siberia: Tuva (n = 20) and Baikal (n = 20); and comparing them with a European (UK) sheep outgroup (n = 14), 41 million variants were called, and signatures of selection were identified. High‐frequency missense mutations on top of selection peaks were found in genes related to immunity (LOC101109746) in the Baikal breed and wool traits (IDUA), cell differentiation (GLIS1) and fat deposition (AADACL3) in the Tuva breed. In addition, genes found under selection owing to haplotype frequency changes were related to wool traits (DSC2), parasite resistance (CLCA1), insulin receptor pathway (SOCS6) and DNA repair (DDB2) in the Baikal breed, and vision (GPR179) in the Tuva breed. Our results present candidate genes and SNPs for future selection programmes, which are necessary to maintain and increase socioeconomic gain from Siberian breeds.

中文翻译：

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两个西伯利亚本地绵羊品种的选择扫描的重测序和签名指出了适应和经济上重要的性状的候选遗传变异

俄罗斯绵羊品种通过提供肉类和羊毛，同时适应极端气候，代表了一项重要的经济资产。对来自西伯利亚的两个俄罗斯品种进行重新测序：图瓦（n  = 20）和贝加尔湖（n  = 20）；并将其与欧洲（英国）羊群（n  = 14）进行比较，调用了4,100万个变体，并鉴定了选择的标志。在与免疫相关的（基因被发现在选择的峰的顶部高频错义突变LOC101109746）在贝加尔品种和羊毛性状（IDUA），细胞分化（GLIS1）和脂肪沉积（AADACL3）。此外，由于单倍型频率变化而在选择下发现的基因与贝加尔湖品种的羊毛性状（DSC2），寄生虫抗性（CLCA1），胰岛素受体途径（SOCS6）和DNA修复（DDB2）有关，以及与之相关的视野（GPR179）。图瓦犬。我们的研究结果为未来的选择计划提供了候选基因和SNP，这些对于维持和增加西伯利亚品种的社会经济收益是必需的。