Individual animals vary in their behaviors. This is true even when they share the same genotype and were reared in the same environment. Clusters of covarying behaviors constitute behavioral syndromes, and an individual's position along such axes of covariation is a representation of their personality. Despite these conceptual frameworks, the structure of behavioral covariation within a genotype is essentially uncharacterized and its mechanistic origins unknown. Passing hundreds of inbred Drosophila individuals through an experimental pipeline that captured hundreds of behavioral measures, we found correlations only between sparse pairs of behaviors. Thus, the space of behavioral variation has many independent dimensions. Manipulating the physiology of the brain, and specific neural populations, altered specific correlations. We also observed that variation in gene expression can predict an individual's position on some behavior axes. This work represents the first steps in understanding the biological mechanisms determining the structure of behavioral variation within a genotype.

中文翻译：

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基因型内行为变异的结构

个别动物的行为各不相同。即使它们具有相同的基因型并在相同的环境中饲养，也是如此。共变行为的簇构成了行为综合症，而个体在这种共变轴上的位置代表了他们的个性。尽管有这些概念上的框架，但基因型内行为协变的结构基本上是未知的，其机制起源尚不清楚。通过捕获数百种行为指标的实验管道，将数百名近交果蝇个体传递出去，我们发现仅在稀疏的行为对之间存在相关性。因此，行为变异的空间具有许多独立的维度。操纵大脑的生理以及特定的神经种群会改变特定的相关性。我们还观察到基因表达的变化可以预测个体在某些行为轴上的位置。这项工作代表着了解决定基因型内行为变异结构的生物学机制的第一步。