The global evolutionary dynamics of influenza viruses ultimately derive from processes that take place within and between infected individuals. Recent work suggests that within-host populations are dynamic, but an in vivo estimate of mutation rate and population size in naturally infected individuals remains elusive. Here we model the within-host dynamics of influenza A viruses using high depth of coverage sequence data from 200 acute infections in an outpatient, community setting. Using a Wright-Fisher model, we estimate a within-host effective population size of 32-72 and an in vivo mutation rate of 3.4x10-6 per nucleotide per generation.

中文翻译：

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急性感染个体中甲型流感病毒的有效种群规模和突变率

流感病毒的全球进化动力最终源自受感染个体内部和之间的过程。最近的工作表明，寄主内的种群是动态的，但是在体内对自然感染个体的突变率和种群规模的估计仍然难以捉摸。在这里，我们使用门诊，社区环境中200例急性感染的高覆盖率序列数据，对甲型流感病毒的宿主内部动态进行建模。使用Wright-Fisher模型，我们估计宿主内有效种群大小为32-72，体内突变率为每代核苷酸每核苷酸3.4x10-6。