The human orthopneumovirus (HRSV) is a major cause of lower respiratory tract infection in children worldwide. Despite decades of efforts, no vaccine is available. In this work, we report mutations that are frequent in vaccine candidates and rare in wild-type genomes, taking into account all the publicly available HRSV sequence data. These mutations are different from the ones already known to attenuate the virus, and thus may contribute to the effort towards producing a live attenuated vaccine against HRSV.

中文翻译：

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人类呼吸道合胞病毒疫苗减毒的基因组学

人正肺病毒（HRSV）是全世界儿童下呼吸道感染的主要原因。尽管经过数十年的努力，仍无法获得疫苗。在这项工作中，我们考虑到所有可公开获得的HRSV序列数据，报告了在候选疫苗中频繁发生而在野生型基因组中罕见的突变。这些突变与已知的减毒病毒突变不同，因此可能有助于产生针对HRSV的减毒活疫苗。