Mitochondria control eukaryotic cell fate by producing the energy needed to support life and the signals required to execute programmed cell death. The biochemical milieu is known to affect mitochondrial function and contribute to the dysfunctional mitochondrial phenotypes implicated in cancer and the morbidities of ageing. However, the physical characteristics of the extracellular matrix are also altered in cancer and in aging tissues. We demonstrate that cells sense the physical properties of the extracellular matrix and activate a mitochondrial stress response that adaptively tunes mitochondrial function via SLC9A1-dependent ion exchange and HSF1-dependent transcription. Overall, our data indicate that adhesion-mediated mechanosignaling may play an unappreciated role in the altered mitochondrial functions observed in aging and cancer.

中文翻译：

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粘附介导的机械信号传递力

线粒体通过产生维持生命所需的能量和执行程序性细胞死亡所需的信号来控制真核细胞的命运。已知生化环境会影响线粒体功能，并促成线粒体功能异常，从而导致癌症和衰老。但是，细胞外基质的物理特性在癌症和衰老组织中也会改变。我们证明细胞感知细胞外基质的物理特性并激活线粒体应激反应，通过依赖SLC9A1的离子交换和HSF1依赖性的转录来适应性地调节线粒体的功能。总体而言，我们的数据表明，粘附介导的机械信号转导在衰老和癌症中观察到的线粒体功能改变中可能没有发挥重要作用。