The sexually transmitted infection (STI) gonorrhoea is an ancient human disease caused by the Gram-negative bacterial pathogen Neisseria gonorrhoeae. Despite decades of research focused on preventing, diagnosing, and treating gonorrhoea, it remains a major global health concern due to its high prevalence, high rates of asymptomatic cases, the severe sequelae that can result from untreated infections, and the increasing difficulty in treating infections caused by multi-drug resistant strains of N. gonorrhoeae. It is estimated that there are more than 87 million cases of gonorrhoea worldwide each year, and the WHO, CDC and Australian National Antimicrobial Resistance (AMR) Strategy have prioritised N. gonorrhoeae as an urgent public health threat for which new therapeutics and a vaccine are needed.

性传播感染（STI）淋病是一种古老的人类疾病，由革兰氏阴性细菌病原体淋病奈瑟氏球菌引起。尽管数十年来的研究专注于预防，诊断和治疗淋病，但由于其高患病率，无症状病例的高发率，未经治疗的感染可能导致的严重后遗症以及治疗感染的难度不断增加，它仍然是全球健康的主要关注点由淋病奈瑟菌的多药耐药菌株引起。据估计，全世界每年有超过8700万例淋病病例，而且WHO，CDC和澳大利亚国家抗菌素耐药性（AMR）策略已将淋病奈瑟氏球菌列为优先事项 作为迫切的公共健康威胁，需要新的疗法和疫苗。