Structural Insights into the TES/TFA Reduction of Differently Substituted Benzofurans: Dihydrobenzofurans or Bibenzyls?,Synlett

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Structural Insights into the TES/TFA Reduction of Differently Substituted Benzofurans: Dihydrobenzofurans or Bibenzyls?
Synlett ( IF 2 ) Pub Date : 2020-10-22 , DOI: 10.1055/s-0040-1705949
Lucia Chiummiento ₁ , Rosarita D’Orsi , Ilaria Caivano , Maria Funicello , Paolo Lupattelli

Affiliation

Abstract

Various polysubstituted benzofurans were reduced by using triethylsilane in trifluoracetic acid. 2,3-Dihydrobenzofurans or bibenzyl compounds were obtained in high yields, depending on the nature of the substituents at C2 and on the benzene ring of the core structure. A p-anisole substituent at C2 of benzofurans always led to the corresponding bibenzyls.